- antifungal (polyene)
Brands/Synonyms : Abelcet
Indications
Dog
1
Dog
3
Therapeutics
Interactions
Compatible with 5% dextrose (for infusion) - do not use other fluid types
Avoid concurrent administration with other drugs that have nephrotoxic potential (e.g., aminoglycoside antibacterials) or that can foster prerenal azotemia (e.g., diuretics)
Rare hypokalemia
Available Formulations
Inj
100 mg/vial
Precautions
Contraindications
Hypersensitivity to the drug
Adverse Side Effects
Nephrotoxicosis is rare at 4 mg/kg q 24h and appears much less severe than with standard amphotericin B
Nephrotoxicosis is rare at 4 mg/kg q 24h and appears much less severe than with standard amphotericin B
Pearls
Infuse only with 5% dextrose (be sure to pre-flush IV lines with 5% dextrose before starting infusion); other fluids may cause precipitation of the drug
Diluted in 5% dextrose to 1 mg/mL each dose before giving as IV infusion
For blastomycosis, largely replaced by oral azoles (itraconazole, fluconazole for central nervous system, eye) unless unable to swallow or urgent/immediate intervention needed
Many dogs treated with this dosage for other systemic mycoses including histoplasmosis and coccidioidomycosis
Infuse only with 5% dextrose (be sure to pre-flush IV lines with 5% dextrose before starting infusion); other fluids may cause precipitation of the drug
Diluted in 5% dextrose to 1 mg/mL each dose before giving as IV infusion
For blastomycosis, largely replaced by oral azoles (itraconazole, fluconazole for central nervous system, eye) unless unable to swallow or urgent/immediate intervention needed
Many dogs treated with this dosage for other systemic mycoses including histoplasmosis and coccidioidomycosis
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